Journal article
Radiobiological parameters in a tumour control probability model for prostate cancer LDR brachytherapy
EJ Her, HM Reynolds, C Mears, S Williams, C Moorehouse, JL Millar, MA Ebert, A Haworth
Physics in Medicine and Biology | IOP PUBLISHING LTD | Published : 2018
Abstract
To provide recommendations for the selection of radiobiological parameters for prostate cancer treatment planning. Recommendations were based on validation of the previously published values, parameter estimation and a consideration of their sensitivity within a tumour control probability (TCP) model using clinical outcomes data from low-dose-rate (LDR) brachytherapy. The proposed TCP model incorporated radiosensitivity (α) heterogeneity and a non-uniform distribution of clonogens. The clinical outcomes data included 849 prostate cancer patients treated with LDR brachytherapy at four Australian centres between 1995 and 2012. Phoenix definition of biochemical failure was used. Validation of t..
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Awarded by Australian Research Council
Funding Acknowledgements
This study was supported by Priority-driven Collaborative Cancer Research Scheme grant (628592), an Australian National Health and Medical Research Council (NHMRC) Project Grant (1126955) and the Australian Research Council grant (DP110102258). Emily Her is supported by an Australian Government Research Training Program Scholarship. Dr Hayley Reynolds is supported by a Movember Young Investigator Grant awarded through Prostate Cancer Foundation of Australia's Research Program. Authors would like to thank Ms Karen Scott and Dr Vanessa Panettieri for their assistance in data analysis.